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How Long Does Percocet Stay in Your System?

What is Percocet?

Percocet is an opioid pain reliever that is commonly prescribed. It is made from a combination of short-acting oxycodone and acetaminophen. It’s a pain reliever that’s used to treat both acute and chronic pain, such as back pain, post-surgical pain, or pain from an accident. However, it is an addictive drug that the Drug Enforcement Administration has classified as a Schedule II controlled substance.

Many people are curious about how long Percocet stays in the body and how long it can be detected in routine drug tests. Understanding how long Percocet remains in the system is dependent on the test, your overall physiology, and factors such as the drug’s half-life. You can easily Buy Percocet Online in USA.

What is the half-life of Percocet?

The half-life of a substance is the amount of time it takes for it to be reduced to half its initial amount in your body. For example, if you take Percocet, the half-life refers to how long it takes for the substance’s concentration in your body to decrease by half. The half-life of Percocet may also be useful in predicting when withdrawal symptoms may occur.

Percocet’s oxycodone component has a half-life of 3.2 to 4 hours because it is a short-acting, immediate-release drug. Similarly, Percocet’s acetaminophen component has a half-life of about three hours. Percocet’s half-life range, on the other hand, varies and may increase if you have poor kidney or liver function.

In most cases, it takes about five half-lives for a drug to be completely eliminated from your system. Percocet is likely to stay in your system for about 20 hours based on a half-life of 4 hours.

Factors Influencing How Long Percocet Remains in Your System

Individual factors can influence how long Percocet remains in your system:

Physiological Factors: A person with impaired kidney or liver function may clear Percocet more slowly than a person with normal kidney and liver function, causing the drug to stay in their system longer.

Drug Interactions: Some drugs, such as the anti-infective rifampin and the seizure medications carbamazepine and phenytoin, can cause the body to clear Percocet faster than expected. Some medications, such as antibiotics like erythromycin, the antifungal ketoconazole, and the HIV medication ritonavir, can cause the painkiller to stay in the body for longer than expected.

Dosage: The higher the Percocet dose and the more frequently you take it, the longer your body may take to clear the drug.


1–2 hours after taking an oral dose, Percocet reaches a peak in the bloodstream. Blood concentrations remain constant for about 6 hours before rapidly decreasing.

This means that most people who rely on Percocet will experience withdrawal symptoms after about 6 hours. If they take more frequent doses, symptoms may appear even sooner.


The amount of time Percocet stays in a person’s system is determined by the testing method used, how quickly their body metabolizes the drug, and a number of other factors. It may even change in the body of a single person over time. Withdrawal symptoms in people recovering from addiction tend to be relatively short-lived, whereas cravings can last for a long time.

A doctor, addiction specialist, or testing laboratory can advise a person on how long Percocet will stay in their system.